S-Adenosylmethionine (AdometTM) is a naturally occurring sulphur-containing physiologic compound synthesized from the aminoacid L-methionine and adenosine triphosphate. It is one of the most active methyl donors produced in the human body and is involved in more than one hundred biochemical pathways and specific processes. In particular it has a regulating effect on mood and brain functions, keeps the liver healthy and supports joint health.

With also a long history of use in other countries as a prescription drug, AdometTM has been introduced into the US market in 1999 under the Dietary Supplement and Health Education Act as an over-the-counter supplement and nowadays is a popular human dietary supplement.

Recently it is also been launched in veterinary field, recommended for its hepato-protective and antioxidant properties being an indirect precursor to glutathione. AdometTM helps liver function of dogs, cats and horses, enhances the mood creating a sensation of well-being and is also useful in providing relief for joint discomfort.

Extensive research studies over the past 5 decades have clearly established the importance of AdometTM in the cellular metabolism and function of all living organisms. Vital to cells' function, stability and activity the deficiency of AdometTM has profound effect on cell growth and may initiate or contribute to abnormalities of cellular structure and function in the liver as well as many other human and animal body tissues.

Gnosis is a worldwide leader of AdometTM production by fermentation; the long experience in the production of this special ingredient and the deep knowledge of its chemical behavior have lead to Gnosis to develop several formulations and products covered by several granted patents and patent pending applications.

The aetiology of most neurodegenerative disorders is multifactorial and consists of an interaction between environmental factors and genetic predisposition. Progression of neurodegenerative diseases in the elderly such as loss of cognitive ability is part of the normal aging process, where methylation is one of the crucial biochemical pathways. The methylation decline brings to a more sensitive oxidative stress; damage to tissue biomolecules, including lipids, proteins and DNA, by free radicals is postulated to contribute importantly to the pathophysiology of oxidative stress.

EZ-Brain® is a new patented product, a proprietary combination of SAM-e and SOD, which may help to improve brain functions by exerting a strong antioxidant effect and by restoring the altered DNA methylation. SAM-e (S-Adenosyl-L-Methionine) and SOD (Superoxide Dismutase) can act in synergism for the treatment of dementia through their ability to restore the correct levels of DNA methylation (therefore gene expression) and the correct oxidative balance.

SOD is one of the most important enzymes involved in the scavenging of dangerous Reactive Oxygen Species (ROS) also known as "free radicals".

> Technical Information
Grade: Oral
Description: Transparent capsules, size 0
SAM-e Assay: 200 mg/capsule
SOD Coated Assay: 1750 IU/capsule
Grade: Oral
Description: Transparent capsules, size 00
SAM-e Assay: 400 mg/capsule
SOD Coated Assay: 3500 IU/capsule

Gnosis pre-clinical and clinical trials on EZ-Brain® are available upon request.

SAM-e is the main methyl-donor in eukaryotes and a principal metabolite of homocysteine pathway. It is involved both in methylation of different cellular substrates (DNA in particular) and in maintaining oxidative balance via glutathione synthesis.