Humans need to maintain an adequate dietary intake of folate during various stages of their lives. Relevant clinical research emphasizes the importance of folate supplementation in different therapeutic areas such as neural-tube defect, male and female infertility, spontaneous abortion, coronary heart disease, macrocytic anemia, methotrexate therapy.

Folate deficiency is related to the reduction of a cell's capacity to synthesize and repair DNA. Eating folate-rich foods may not provide the recommended daily dosage; thus the need for supplementation. In recent years evidence has shown that reduced folate supplementation present relevant advantages vs folic acid. The rational use of such reduced folates (particularly reduced and methylated) is derived from the inability of a part of world's population to assimilate and metabolize folic acid from food or supplements.

The multidisciplinary research team at Gnosis has intensely researched this category of products and today Gnosis is the only manufacturer of three folate products that can claim GRAS status and NDIN with advanced chemical and clinical characteristics.

The term folate is generically used to represent a member of the B-vitamin family and is a collective term for a number of chemical forms that are structurally-related with similar biological activity to folic acid.

Human beings cannot synthesize folate in the body and must obtain them from dietary source such as leafy green vegetables, fruits and some legumes; however, naturally occurring folates in foods are susceptible to oxidation and losses can occur during food processing, manufacturing and storage. Fortification of foods with folate is known to compensate for these losses.


Irrespective of whether ingested food contains natural or synthetically-derived folates, these are metabolized to 5-methyltetrahydrofolate, which is considered the biologically active form of the B-vitamin folic acid.

Extrafolate® is the calcium salt of (6R,S)-5-methyltetrahydrofolic acid. It can be used as a valid alternative to folates supplementation reducing homocysteine levels and supporting normal cellular proliferation, vascular endothelial function, cardiovascular health, nervous system function; in particular, it is suggested before and during pregnancy in order to protect against a number of congenital malformations including neural tube (malformations of the spine, skull, and brain).

> Technical Information
Grade: Oral
Packing size: 1 Kg, 5 Kg LDPE bags
Regulatory status: GRAS, NDI
CAS number: 26560-38-3
Chemical name:
N-[4-[[[(6R,S)-2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-L-glutamic acid, calcium salt

Because folate is not stored in the body in large amounts eating folate-rich foods may not provide the recommended daily dosage. An unbalanced diet, particular physiological conditions (pregnancy and lactation, malabsorbtion, children growing) and some drugs treatments can cause folate deficiencies requiring a supplementation.