S-Adenosylmethionine (AdometTM) is a naturally occurring sulphur-containing physiologic compound synthesized from the aminoacid L-methionine and adenosine triphosphate. It is one of the most active methyl donors produced in the human body and is involved in more than one hundred biochemical pathways and specific processes. In particular it has a regulating effect on mood and brain functions, keeps the liver healthy and supports joint health.

With also a long history of use in other countries as a prescription drug, AdometTM has been introduced into the US market in 1999 under the Dietary Supplement and Health Education Act as an over-the-counter supplement and nowadays is a popular human dietary supplement.

Recently it is also been launched in veterinary field, recommended for its hepato-protective and antioxidant properties being an indirect precursor to glutathione. AdometTM helps liver function of dogs, cats and horses, enhances the mood creating a sensation of well-being and is also useful in providing relief for joint discomfort.

Extensive research studies over the past 5 decades have clearly established the importance of AdometTM in the cellular metabolism and function of all living organisms. Vital to cells' function, stability and activity the deficiency of AdometTM has profound effect on cell growth and may initiate or contribute to abnormalities of cellular structure and function in the liver as well as many other human and animal body tissues.

Gnosis is a worldwide leader of AdometTM production by fermentation; the long experience in the production of this special ingredient and the deep knowledge of its chemical behavior have lead to Gnosis to develop several formulations and products covered by several granted patents and patent pending applications.



Adogran is a formulated bulk powder consisting of coated granules containing
S-Adenosyl-L-Methinonine (SAMe).

> Technical Information

This innovative formulation is available in two different grades ("high dosage" and "low dosage") with superior organoleptic properties versus SAMe.

Grade: Oral
Packing size: 1 Kg - 5 Kg - 25 Kg, in LDPE bags
High Dosage formulation: SAMe ion assay greater than 38%
Low Dosage formulation: SAMe ion assay greater than 32%

Coated granules protect SAMe from possible interaction with environmental factors and/or other ingredients added in finished formulations, guaranteeing availability of active substance when it is taken orally. Adogran is suitable for human and animal consumption and finds its best application when dosed in capsules and sachets.