S-Adenosylmethionine (AdometTM) is a naturally occurring sulphur-containing physiologic compound synthesized from the aminoacid L-methionine and adenosine triphosphate. It is one of the most active methyl donors produced in the human body and is involved in more than one hundred biochemical pathways and specific processes. In particular it has a regulating effect on mood and brain functions, keeps the liver healthy and supports joint health.

With also a long history of use in other countries as a prescription drug, AdometTM has been introduced into the US market in 1999 under the Dietary Supplement and Health Education Act as an over-the-counter supplement and nowadays is a popular human dietary supplement.

Recently it is also been launched in veterinary field, recommended for its hepato-protective and antioxidant properties being an indirect precursor to glutathione. AdometTM helps liver function of dogs, cats and horses, enhances the mood creating a sensation of well-being and is also useful in providing relief for joint discomfort.

Extensive research studies over the past 5 decades have clearly established the importance of AdometTM in the cellular metabolism and function of all living organisms. Vital to cells' function, stability and activity the deficiency of AdometTM has profound effect on cell growth and may initiate or contribute to abnormalities of cellular structure and function in the liver as well as many other human and animal body tissues.

Gnosis is a worldwide leader of AdometTM production by fermentation; the long experience in the production of this special ingredient and the deep knowledge of its chemical behavior have lead to Gnosis to develop several formulations and products covered by several granted patents and patent pending applications.



A critical step toward the application of AdometTM in the pharmaceutical and nutritional fields has been the development of salts that provide sufficient stability with superior quality throughout the shelf life of the product.

Specific aspects of this superior quality include better stability of the compound, less degradation, adequate absorption after oral administration, and adequate penetration into the targeted organs.

> Technical Information
Grade: Oral
Packing size: 10 kg - 25 kg, in LDPE bags
(S,S) Isomer: Greater than 75%
Certifications: Kosher, KOF-K

Gnosis has more than 20 years of experiences in manufacturing S-Adenosyl-methionine, and has developed and patented the production method and the related purification technology for stable salts, using a selected highly productive yeast and using fermentation technologies which generate a superior quality of the ingredient.

AdometTM is suitable for nutritional application in the form of disulphate ptoluensulfonate salt. It contains more than 75% of (S,S) isomer, recognized as the effective bioavailable form of the ingredient, and is totally obtained through a biofermentation process in a pharmaceutical manufacturing operations.