S-Adenosylmethionine (AdometTM) is a naturally occurring sulphur-containing physiologic compound synthesized from the aminoacid L-methionine and adenosine triphosphate. It is one of the most active methyl donors produced in the human body and is involved in more than one hundred biochemical pathways and specific processes. In particular it has a regulating effect on mood and brain functions, keeps the liver healthy and supports joint health.

With also a long history of use in other countries as a prescription drug, AdometTM has been introduced into the US market in 1999 under the Dietary Supplement and Health Education Act as an over-the-counter supplement and nowadays is a popular human dietary supplement.

Recently it is also been launched in veterinary field, recommended for its hepato-protective and antioxidant properties being an indirect precursor to glutathione. AdometTM helps liver function of dogs, cats and horses, enhances the mood creating a sensation of well-being and is also useful in providing relief for joint discomfort.

Extensive research studies over the past 5 decades have clearly established the importance of AdometTM in the cellular metabolism and function of all living organisms. Vital to cells' function, stability and activity the deficiency of AdometTM has profound effect on cell growth and may initiate or contribute to abnormalities of cellular structure and function in the liver as well as many other human and animal body tissues.

Gnosis is a worldwide leader of AdometTM production by fermentation; the long experience in the production of this special ingredient and the deep knowledge of its chemical behavior have lead to Gnosis to develop several formulations and products covered by several granted patents and patent pending applications.



In comparison with conventional tablet manufacturing, capsules production presents technical
advantages without requiring expensive and consuming operations. Capsules are odorless, tasteless,
easy to swallow and guarantee extensive possible combinations and formulations with actives
and excipients.

> Technical Information
Grade: Oral
Packing size: 5Kg - 10 kg - 25 kg, in LDPE bags
(S,S) Isomer: Greater than 70%

Until now these dosage forms were precluded for S-Adenosyl-methionine due to technical restrictions. Capsules tends to absorb the moisture, affecting SAM-e properties and the shelf-life of finished products. Capsules formulations with SAM-e are now possible thanks to the new patented stabilized powder, SAM-e Dried Mix, that opens the doors to a widening range of applications.